Director, office of health and safety centers for disease control and prevention atlanta, ga 30333 adapted from the cdcnih 3rd edition of biosafety in microbiological and biomedical laboratories introduction. Biosafety, in medicine and health care settings, specifically refers to proper handling of organs or tissues from biological origin, or genetic therapy products, viruses with respect to the environment, to ensure the safety of health care workers. While the multidisciplinary membership solicited from the different sectors should be applauded, we. To protect human health and the environment, state, local and federal governments, and others must make daily decisions about the risks of exposures to environmental contaminants. Vanderbilt environmental health and safety 3222057. Chapman university is using the bmbl fifth edition, 2009 as the basis for this biosafety manual. It also helps maintain our academic excellence and integrity and ensure research funds from the national institutes of health nih and other funding sources. If you receive care at boynton health, you can call their nurse line at 6126257900. The canadian biosafety handbook cbh, 2 nd edition, 2016 is intended as a companion document to the canadian biosafety standard cbs, 2 nd edition, 2015. Department of agriculture usda requirements to secure pathogens held at usda biosafety level3 bsl3 facilities. Biosafety environmental health and safety dalhousie. Biosafety recommendations for the contained use of. The institute for health metrics and evaluation is an independent population health research center at uw medicine, part of the university of washington, that provides rigorous and comparable measurement of the worlds most important health problems.
Ehs provides biosafety training and also manages the universitys biological waste disposal program. Biosafety resource book food and agriculture organization of the. Biological safety program biological safety uthealth. Biosafety permit holders, laboratory supervisors, biosafety committee, associate deans research for. Such materials would include, but are not limited to. Biological agents are assigned to biosafety levels bsl based on the risk they pose to human health and the environment. Measles virus, salmonellae, toxoplasma species, hepatitis b virus, primary human cells, viral vectors 4. One important biosafety element suggested for all 4 biosafety levels is biosafety training. Epas human health risk assessment hhra program is designed to provide robust and responsive risk assessment support to risk management decisions aimed at protecting human health and the environment.
Contact ohp for information on the hepatitis b vaccination. Biosafety is a set of specialized practices for safe handling and disposal of infectious organisms or biological material, which may harbor infectious organisms. Viral vector safety guidance bsds environmental health. Introduction concern for health has traditionally underlain much of the political priority given to environmental issues in oecd countries. Good biological safety practices protect the environment from release of potentially harmful agents.
The manual is part of msus biosafety program, which was established to. We work hard so that the campus and your work environment are as safe as possible, to protect you from harm and to prevent accidents and injuries. Other infectious agents as outlined in laws, regulations, or guidelines. Principal investigators who wish to conduct research involving microbial agents or cell lines are required to register with the institutional biosafety committee ibc. All infectious agents or substances requiring handling at biosafety level 2 must be registered with the ibc. No needs helper virus cmv, adenovirus, herpesvirus, vaccinia. Developing a culture of biosafety is intended for any laboratory performing testing on infectious agents or clinical specimens that could contain infectious agents in the united states. National biosafety authority biosafety regulations. It is through their absolute commitment to quality, technical accuracy, and dedication to the professional. It is designed to provide laboratories with the broad recommendations for. Human health hazards the potential of k12 strains to present risks to human health are examined in this assessment by analyzing k12 in terms of 1 the phenotypic traits relevant to colonization of the colon, and 2 toxin production.
Opportunity the purpose of this letter is to request input from principal investigators and laboratory personnel into. It is recognized that use of potentially pathogenic microorganisms, other biological materials, and organisms containing recombinant or synthetic nucleic acid molecules is. Usda security policies and procedures for biosafety level3 facilities opi. Researchers and other personnel who work with human and nonhuman primates fluids, tissues or cells including cell lines are required to take bloodborne pathogen training oh 218 anually and be offered hepatitis b vaccination free of charge by the university. Biological safety manual environment, health and safety. Cdc nih biosafety in microbiological and biomedical laboratories bmbl.
Suitable for work involving agents of moderate potential hazard to personnel and the environment examples. The centers for disease control and prevention cdc, or the department of health and human services hhs cannot attest to the accuracy of a nonfederal site and the listing of nonfederal resources and tools below does not constitute an endorsement by hhs or any of its employees of the sponsors of the information or products. Research with microbes and cell lines environment, health. The impact of environmental risk factors on health are extremely varied and complex in. We want to stress the importance of working safely and responsibly with biological and. Bsl2 is suitable for work involving agents that pose moderate hazards to personnel and the environment. In general, the biosafety level recommended for working with biohazardous material in vivo and in vitro are comparable. The goals of the biosafety program are to protect personnel from exposure to infectious agents, to prevent environmental contamination, to provide an environment for high quality research while maintaining a safe work place, and to comply with applicable federal, state and. It is argued that the addition of this added high frequency 5g radiation to an already complex mix of lower frequencies, will contribute to a negative public health outcome both from both physical and mental health perspectives. Harvard biosafety manual 2016 page 3 introduction and roles of key university personnel. Introduction the occurrence of laboratoryassociated infections evolution of national biosafety guidelines risk criteria for establishing ascending levels of containment agent summary statements biosecurity using bmbl looking ahead references chapter 2. Cultures and stocks consist of wastes infectious to humans and include specimen cultures.
At the global level, heli is developing tools and resources relevant to. The bill also establishes the national biosafety committee in section 9 a multidisciplinary committee to advise the competent authority. Effective treatment and preventive measures are available and the. In this booklet you will find all the information that was already present in the earlier editions. All other waste services are operating as normal at this time. Environment, nature and energy, focusing on the environment. The hhra program is the world leader in providing both an essential portfolio of risk assessment products. See the safe campus coronavirus public health alert page.
This specialized agency of the united nations published the first edition of its laboratory biosafety manual in 1983. Biosafety manual and any recommendations made by iu ibc or iuehs biosafety preempts recommendations that follow from the bmbl for. Chapman university biosafety manual 3 while not a regulation, the bmbl has been revised several times and is commonly seen as the gold standard for biosafety. For a summary of biosafety work practices, personal protective equipment and laboratory facilities, refer to the cdcnih biosafety in microbiological and biomedical laboratories bmbl 5th edition. The committee for laboratory and environmental biosafety cleb serves as uc berkeleys institutional biosafety committee ibc. Indiana university is actively committed to preserving the health and safety of its students, staff, and faculty, and to protecting the environment and the community. Biosafety in microbiological and biomedical laboratories. May be associated with insertional mutagenesis and cancer. Security of pathogens held at nonbsl3 facilities is covered in another. We hope that sharing our processes through this brief.
Looking for health response and preparation information for covid19. Public health agency of canada phac is developing human pathogens and toxins regulations. Principles and concepts of biosafety environmental health. Can be potentially reactivated later in the presence of a helper virus and produce infection. The secretariat of the convention on biological diversity world trade centre 393 st. A pathogen that can cause disease in humans or animals but is unlikely to be a serious hazard. Inserts itself on human chromosome 19 and remains latent.
Such factors as severity of disease caused by the agent routes of exposure, and virulence are used when determining the most appropriate bsl. Biosafety work practices environmental health and safety. Concepts of biosafety and biosecurity deal with related but distinctly different issues. Research involving plant diseases, plant pests, or genetically modified plants requires containment from the natural environment and from agricultural crops and markets. Biosafety practices are used in the proper handling of biohazardous organisms. Bsl based on the risk they pose to human health and the environment. The third edition of the who laboratory biosafety manual is a helpful reference and guide to nations that accept the challenge to develop and establish national codes of practice for securing microbiological assets, yet ensuring their availability for clinical, research and epidemiological purposes. Purpose the purpose of this letter is to inform you about the plan for updating the biosafety program to meet legislative requirements. Viral vector safety guidance bsds biosafety programs. This is the third, revised edition of the booklet biosafety in the laboratory. The intent of the biosafety program at queens university, and the purpose of the queens biosafety manual, is to guide personnel in how to work safely with biological material that can be hazardous to people andor animals. In addition to the bmbl and rdna guidelines, previously described, the osha bloodborne pathogen standard may apply to research laboratories where blood, other human body fluids, primary human tissue explants and their clonal. The biosafety environmental release regulations, 2011.
Biosafety is a wellestablished concept with a widelyaccepted meaning and international guidance on how it is put into practice at the national level. Biosafety, which is the clearing house for biotechnology applications internationally 10 part iv risk and safety assessment and management clause 29 emphasizes safety in using biotechnology by providing for measures to be taken to minimize or avoid risk to human health and the environment arising from actual or potential contact with a gmo. Guidelines for research involving recombinant or synthetic nucleic acid molecules pdf 1. Canadian biosafety handbook, second edition canada. Usda security policies and procedures for biosafety level 3. Biosafety means the need to protect human and animal health and environment from the possible adverse effects of the products of modern biotechnology. This booklet contains the text of the cartagena protocol on biosafety to the convention on biological diversity, which starts on page 2. Welcome yale university is committed to health, safety and environmental protection in all of its programs and activities. Cooperation agreement on biosafety belgian biosafety server.
This biosafety manual has been developed by the environmental health and safety ehs department at michigan state university. Biosafety is defined as the safety for human health and the environment, including the protection of biodiversity, related to the use of genetically modified organisms or microorganisms, and to the contained use of organisms pathogen for humans. Principles of biosafety fact sheet biosafety is a practice. As part of their mission, both inspection services may perform sampling in order to verify whether the implemented containment and the practices of work are adequate and sufficient to offer maximal protection of human health and environment from biological risks. If you have been in contact with a covid19 patient or are exhibiting symptoms, contact your preferred health care provider for further guidance. Universal waste electronics recycling is suspended until further notice, effective march 19, 2020. Only a few alterations have been made, especially in the text concerning decontamination and inactivation. Agricultural research service 1 purpose the purpose of this manual is to define u.
Plant research generally does not pose a risk to human health but can pose a hazard to other plants and the environment. Biosafety level 2 bsl2 laboratory practices outlined below are basic rules for operating a laboratory at bsl2. All individuals are required to file a registration with the office of prospective health biological safety, if they wish to work with a covered biohazard biotoxins, allergens, biohazardous agents, microorganisms with an assigned biosafety level 2 or higher, human tissues, body fluids and commercially available human cell lines, any. Human, animal and plant materials may harbor biohazardous organisms or agents and such materials must be handled accordingly. Safety and health peosh and applies to public employees in the state of nj. Biosafety introduction to the queens biosafety program and manual. The recommendations below describe practices, safety equipment and facilities for experiments with animals infected with agents that cause, or may cause, human infection.
Research ethic and complianceinstitutional biosafety committee ibc. Cleb is comprised of subject matter experts, an animal health expert, an occupational physician, as well as community members. This biosafety manual provides a summary of pertinent federal and local government regulations, information about safe work practices, safety equipment and personal protective. Biosafety, in medicine and health care settings, specifically refers to proper handling of organs or tissues from biological origin, or genetic therapy products, viruses with respect to the environment, to ensure the safety of health care workers, researchers, lab staff, patients, and the general public. The principal investigator pi is ultimately responsible for the enforcement of these practices. Storing human foods or drinks anywhere in the laboratory working areas is prohibited. Biosafety committee resources yale environmental health. Biosafety manual university of massachusetts amherst. Cleb is comprised of subject matter experts, an animal health expert, and an occupational physician, as well as community members. The biological safety program is responsible for providing support to the university of texas health science center at houston students and personnel concerning the recognition, evaluation, and control of chemical, biological, and physical hazards. The management of biohazardous waste is administered by environmental health and safety ehs in accordance with state of texas regulations and university policy developed in conjunction with the institutional biosafety committee ibc. Refer to the references below for additional rules that may apply to your specific research. This includes animal and plant pathogens, certain tissue cultures and live animals.
The cartagena protocol on biosafety, a supplement to the convention on biological diversity, aims to ensure the safe handling, transport and use of organisms that have been modified using modern biotechnology. Researchers and other personnel who work with human and nonhuman primates fluids, tissues or cells. Bsl 2 is the biosafety level used for work with human blood, body fluids. Written documents that are expected to be removed from the laboratory need to. Footnote 5 it is a guidance document for canadian facilities where human and terrestrial animal pathogens are handled, that updates the guidelines originally published as part ii of the. Environment, health and safety 2500 university drive nw. Biological safety helps protect the uw community of students, faculty, staff and visitors. Biosafety program stakeholder input into training requirements. Principles and concepts of biosafety environmental. Ofice of environment, health safety 3 return to table of contents introduction to cleb the committee for laboratory and environmental biosafety cleb serves as uc berkeleys institutional biosafety committee ibc. California occupational safety and health administration calosha. Health canada, health protection branch lab centre for disease control laboratory biosafety guidelines national academy press biosafety in the laboratory prudent practices for the handling and disposal of infectious materials world health organization laboratory biosafety manual module 4 mechanical, electrical, plumbing considerations i. Decontamination and reuse of n95 respirators with hydrogen. Provision of basic training in biosafety is considered a best practice and is usually provided by the biosafety officer or occupational health specialist to visitors, students and workers in biological laboratories.
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